GPER MEDIATES THE UP-REGULATION OF FATTY ACID SYNTHASE (FASN) INDUCED BY 17β-ESTRADIOL IN CANCER CELLS AND CANCER-ASSOCIATED FIBROBLASTS (CAFs)
نویسندگان
چکیده
Background: Fatty acid synthase (FASN) is a key lipogenic enzyme regulated by various factors including estrogens. Results: GPER mediates FASN expression and activity induced by estrogens in cancer cells. Conclusion: Fatty acid biogenesis is regulated by estrogens through GPER. Significance: GPER may be included among the transduction mediators involved by estrogens in regulating FASN expression and activity.
منابع مشابه
Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs)
MicroRNAs (miRNAs) are small non coding RNA molecules that play a crucial role in several pathophysiological conditions, including cancer. The stimulation of hormone-sensitive tumors by estrogens are mediated by estrogen receptor (ER)α and G protein estrogen receptor (GPER). Previous studies have reported that ERα regulates miRNA expression, while this ability of GPER remains to be elucidated. ...
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